Endocrine Abstracts

Urinary steroid profiling by capillary gas chromatography is useful for identification of disordered steroid metabolism and, when 24h collections are made, for determination of steroid production rates. We have noted a substantial clinical demand for analysis of random collections, most commonly from children with precocious puberty and a general belief that relating steroid levels to creatinine would offset the disadvantage of a short collection. Given the known circadian var...

While the hypothalamo-pituitary axis is known to contain high levels of basic FGF (FGF2) and its high affinity receptor FGFR1, the physiological role of FGF2 in this region needs elucidation. Here, we demonstrate that FGF2 and arginine vasopressin (AVP) co-localize within the cytoplasm of nearly all supraoptic and paraventricular magnocellular neurons of human hypothalamus as well as the axonal processes of the neurohypophysis. High-resolution confocal imaging indicates that F...

A 75-year-old female presented with 12kg weight loss and malaise, 18 months after a diagnosis of type 2 diabetes mellitus. Abdominal CT scanning demonstrated bilateral adrenal masses and her symptoms responded rapidly to empirical treatment with dexamethasone. CT guided biopsy demonstrated adrenal hyperplasia.Centripetal weight distribution and proximal myopathy were prominent, and serum cortisol failed to suppress following standard 48h low dose (662nm...

Introduction: Polycystic ovary syndrome (PCOS) affects 10% of women and is associated with a 2-3fold risk of type 2 diabetes (T2D), hypertension, fatty liver and cardiovascular disease. Androgen excess has been implicated as a major contributor to metabolic risk in PCOS. We aimed to identify PCOS sub-types with distinct androgen profiles and compare their cardiometabolic risk.Methods: We cross-sectionally studied 488 tre...